SATB1

SATB1
Estructures disponibles
PDB	Cerca ortòloga: PDBe RCSB
Llista de codis id de PDB
	1YSE, 2L1P, 2O49, 2O4A, 3NZL, 3TUO, 2MW8
Identificadors
Àlies	SATB1 (HUGO), SATB homeobox 1, DEFDA, KTZSL, DNA-binding protein SATB1/SATB2, SATB1/SATB2, IPR039673
Identif. externs	OMIM: 602075 MGI: 105084 HomoloGene: 2232 GeneCards: SATB1 OMA: SATB1 - orthologs
Localització del gen (humà)
	Cromosoma: 3 (humà)
Fi	18.445.588 bp
Localització del gen (ratolí)
	Cromosoma: 17 (ratolí)
Fi	52.140.318 bp
Patró d'expressió d'ARN
	Més explicacions
	orbitofrontal cortex ; ; frontal pole ; ; tim; ; Brodmann area 46 ; ; lòbul parietal; ; Gir postcentral; ; paròtide; ; Brodmann area 10 ; ; Escorça entorrinal; ; Brodmann area 23 ;
	Més explicacions
	tim; ; queixal; ; barrel cortex ; ; zigot; ; secondary oocyte ; ; Rostral migratory stream ; ; substància negra; ; glàndula lacrimal; ; múscul vast lateral; ; sang;
	Més referències a dades d'expressió
	Més referències a dades d'expressió
Ontologia genètica
Funció molecular	DNA binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; DNA-binding transcription factor activity ; chromatin binding ; unió proteica ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; double-stranded DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; sequence-specific DNA binding ;
Component cel·lular	PML body ; nuclear matrix ; nucleoplasma ; cromatina ; nucli cel·lular ; nuclear body ;
Procés biològic	reflex ; CD4-positive, alpha-beta T cell differentiation ; CD8-positive, alpha-beta T cell differentiation ; chromatin remodeling ; activated T cell proliferation ; regulació de la transcripció, modelat amb ADN ; negative regulation of transcription by RNA polymerase II ; chromatin organization ; transcripció, plantilla d'ADN ; epidermis development ; histone methylation ; procés viral ; T cell activation ;
	Fonts: Amigo / QuickGO
Ortòlegs
	6304
	20230
	ENSG00000182568
	ENSMUSG00000023927
	Q01826
	Q60611
	NM_001131010; NM_001195470; NM_002971; NM_001322871; NM_001322872; NM_001322873; NM_001322874; NM_001322875; NM_001322876
	NM_001163630; NM_001163631; NM_001163632; NM_009122; NM_001357636; NM_001357637; NM_001357638; NM_001357640
	NP_001124482; NP_001182399; NP_001309800; NP_001309801; NP_001309802; NP_001309803; NP_001309804; NP_001309805; NP_002962
	NP_001157102; NP_001157103; NP_001157104; NP_033148; NP_001344565; NP_001344566; NP_001344567; NP_001344569
	Wikidata
Veure/Editar gen humà	Veure/Editar gen del ratolí

SATB1 (de l'anglès Special AT-rich sequence-binding protein-1, proteïna d'unió a seqüències especials riques en AT 1) és una proteïna que en humans està codificada pel gen SATB1.^[5]

Funció

SATB1 actua d'organitzador de la cromatina i com a factor de transcripció, integrant l'arquitectura d'alt ordre de la cromatina i la regulació gènica.^[6] Estudis recents han aclarit el paper de SATB1 en l'organització del loopscape de cromatina i la seva naturalesa dinàmica en resposta a estímuls fisiològics.^[7] A nivell genòmic, sembla que SATB1 jugaria un paper en l'organització de la cromatina que es troba a punt per a la transcripció. SATB1 organitza el locus del Complex Major d'Histocompatibilitat-1 (MHC-1) en diversos bucles de cromatina lligant MARs a la matriu nuclear a distàncies determinades. El silenciament de SATB1 imita els efectes de l'IFN-γ sobre l'arquitectura dels bucles de cromatina del locus de MHC-1 i l'expressió alterada de gens dins el locus. També s'ha mostrat que SATB1 pot induir el creixement de tumors i metàstasis en càncers de mama mitjançant una alteració en l'expressió de molts gens.

Interaccions

SATB1 presenta interaccions amb HDAC1,^[8] SMARCA5,^[8] MTA2,^[8] CHD4,^[8] CUTL1,^[9] POLR2J^[10] i BAZ1A.^[8]

Referències

1 2 3 GRCh38: Ensembl release 89: ENSG00000182568 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023927 – Ensembl, May 2017
↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Entrez Gene: SATB1 SATB homeobox 1».
↑ Pavan Kumar P, Purbey PK, Sinha CK, Notani D, Limaye A, Jayani RS, Galande S «Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo». Mol. Cell, 22, 2, Abril 2006, p. 231–43. DOI: 10.1016/j.molcel.2006.03.010. PMID: 16630892.
↑ Galande S, Purbey PK, Notani D, Kumar PP «The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1». Curr. Opin. Genet. Dev., 17, 5, Octubre 2007, p. 408–14. DOI: 10.1016/j.gde.2007.08.003. PMID: 17913490.
1 2 3 4 5 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature [Anglaterra], 419, 6907, Octubre 2002, p. 641–5. DOI: 10.1038/nature01084. ISSN: 0028-0836. PMID: 12374985.
↑ Liu, J; Barnett A, Neufeld E J, Dudley J P «Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation». Mol. Cell. Biol. [Estats Units], 19, 7, Juliol 1999, p. 4918–26. ISSN: 0270-7306. PMC: 84297. PMID: 10373541.
↑ Durrin, Linda K; Krontiris Theodore G «The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11». Genomics [Estats Units], 79, 6, Juny 2002, p. 809–17. DOI: 10.1006/geno.2002.6772. ISSN: 0888-7543. PMID: 12036295.

Bibliografia

Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T «A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition». Cell, 70, 4, 1992, p. 631–45. DOI: 10.1016/0092-8674(92)90432-C. PMID: 1505028.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. «Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening». Genomics, 23, 1, 1995, p. 42–50. DOI: 10.1006/geno.1994.1457. PMID: 7829101.
Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T «A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1». Mol. Cell. Biol., 14, 3, 1994, p. 1852–60. PMC: 358543. PMID: 8114718.
Xu L, Deng HX, Xia JH, et al. «Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization». Cytogenet. Cell Genet., 77, 3–4, 1997, p. 205–6. DOI: 10.1159/000134577. PMID: 9284917.
Reddy PH, Stockburger E, Gillevet P, Tagle DA «Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method». Genomics, 46, 2, 1998, p. 174–82. DOI: 10.1006/geno.1997.5044. PMID: 9417904.
Escalier D, Allenet B, Badrichani A, Garchon HJ «High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein». J. Immunol., 162, 1, 1999, p. 292–8. PMID: 9886398.
Liu J, Barnett A, Neufeld EJ, Dudley JP «Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation». Mol. Cell. Biol., 19, 7, 1999, p. 4918–26. PMC: 84297. PMID: 10373541.
Galande S, Dickinson LA, Mian IS, et al. «SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis». Mol. Cell. Biol., 21, 16, 2001, p. 5591–604. DOI: 10.1128/MCB.21.16.5591-5604.2001. PMC: 87280. PMID: 11463840.
Kieffer LJ, Greally JM, Landres I, et al. «Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3». J. Immunol., 168, 8, 2002, p. 3915–22. PMID: 11937547.
Durrin LK, Krontiris TG «The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11». Genomics, 79, 6, 2002, p. 809–17. DOI: 10.1006/geno.2002.6772. PMID: 12036295.
Yasui D, Miyano M, Cai S, et al. «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature, 419, 6907, 2002, p. 641–5. DOI: 10.1038/nature01084. PMID: 12374985.
Strausberg RL, Feingold EA, Grouse LH, et al. «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A., 99, 26, 2003, p. 16899–903. DOI: 10.1073/pnas.242603899. PMC: 139241. PMID: 12477932.
Cai S, Han HJ, Kohwi-Shigematsu T «Tissue-specific nuclear architecture and gene expression regulated by SATB1». Nat. Genet., 34, 1, 2003, p. 42–51. DOI: 10.1038/ng1146. PMID: 12692553.
Fujii Y, Kumatori A, Nakamura M «SATB1 makes a complex with p300 and represses gp91(phox) promoter activity». Microbiol. Immunol., 47, 10, 2004, p. 803–11. PMID: 14605447.
Gerhard DS, Wagner L, Feingold EA, et al. «The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)». Genome Res., 14, 10B, 2004, p. 2121–7. DOI: 10.1101/gr.2596504. PMC: 528928. PMID: 15489334.
Gocke CB, Yu H, Kang J «Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates». J. Biol. Chem., 280, 6, 2005, p. 5004–12. DOI: 10.1074/jbc.M411718200. PMID: 15561718.
Wen J, Huang S, Rogers H, et al. «SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression». Blood, 105, 8, 2005, p. 3330–9. DOI: 10.1182/blood-2004-08-2988. PMID: 15618465.
Seo J, Lozano MM, Dudley JP «Nuclear matrix binding regulates SATB1-mediated transcriptional repression». J. Biol. Chem., 280, 26, 2005, p. 24600–9. DOI: 10.1074/jbc.M414076200. PMID: 15851481.
Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T «A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage». Cell Cycle, 4, 8, 2006, p. 1099–106. PMID: 15970696.
Rual JF, Venkatesan K, Hao T, et al. «Towards a proteome-scale map of the human protein-protein interaction network». Nature, 437, 7062, 2005, p. 1173–8. DOI: 10.1038/nature04209. PMID: 16189514.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182568 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023927 – Ensembl, May 2017

[3] «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] «Entrez Gene: SATB1 SATB homeobox 1».

[pmid16630892-6] Pavan Kumar P, Purbey PK, Sinha CK, Notani D, Limaye A, Jayani RS, Galande S «Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo». Mol. Cell, 22, 2, Abril 2006, p. 231–43. DOI: 10.1016/j.molcel.2006.03.010. PMID: 16630892.

[pmid17913490-7] Galande S, Purbey PK, Notani D, Kumar PP «The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1». Curr. Opin. Genet. Dev., 17, 5, Octubre 2007, p. 408–14. DOI: 10.1016/j.gde.2007.08.003. PMID: 17913490.

[pmid12374985-8] 1 2 3 4 5 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature [Anglaterra], 419, 6907, Octubre 2002, p. 641–5. DOI: 10.1038/nature01084. ISSN: 0028-0836. PMID: 12374985.

[pmid10373541-9] Liu, J; Barnett A, Neufeld E J, Dudley J P «Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation». Mol. Cell. Biol. [Estats Units], 19, 7, Juliol 1999, p. 4918–26. ISSN: 0270-7306. PMC: 84297. PMID: 10373541.

[pmid12036295-10] Durrin, Linda K; Krontiris Theodore G «The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11». Genomics [Estats Units], 79, 6, Juny 2002, p. 809–17. DOI: 10.1006/geno.2002.6772. ISSN: 0888-7543. PMID: 12036295.

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