D-amino acid dehydrogenase (quinone)

D-amino acid dehydrogenase (quinone)
Identifiers
EC no.1.4.5.1
Databases
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BRENDABRENDA entry
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D-amino acid dehydrogenase (quinone) (EC 1.4.5.1, DadA) is an enzyme with systematic name D-amino acid:quinone oxidoreductase (deaminating).[1] This enzyme catalyses the following chemical reaction

D-amino acid + H2O + quinone 2-oxo carboxylate + NH3 + quinol

For example, the bacterium Escherichia coli B acts on D-phenylalanine:[2]

2D representation of the chemical structure of Q26841253.
D-phenylalanine
+ a quinone
 
 
H2O
NH3
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
H2O
NH3
 
2D representation of the chemical structure of phenylpyruvic acid .
phenylpyruvic acid
+ a quinol
 

This enzyme is iron-sulfur flavoprotein.[3]

References

  1. ^ Tanigawa M, Shinohara T, Saito M, Nishimura K, Hasegawa Y, Wakabayashi S, Ishizuka M, Nagata Y (January 2010). "D-Amino acid dehydrogenase from Helicobacter pylori NCTC 11637". Amino Acids. 38 (1): 247–55. doi:10.1007/s00726-009-0240-0. PMID 19212808. S2CID 29038373.
  2. ^ Olsiewski PJ, Kaczorowski GJ, Walsh C (May 1980). "Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B". The Journal of Biological Chemistry. 255 (10): 4487–94. doi:10.1016/S0021-9258(19)85517-5. PMID 6102989.
  3. ^ Enzyme 1.4.5.1 at KEGG Pathway Database.


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