List of tallest buildings in Clayton, Missouri

Clayton is the 44th largest city in Missouri and the county seat of St. Louis County, Missouri. The city has a population of 17,512 people as of 2025.^[1] The city has 11 high-rises which stand over 262 ft (80 m) tall. As of January 2026, the tallest building in Clayton is Centene Plaza C which stands 419 ft (128 m) tall.

This list ranks buildings in Clayton that stand at least 262 ft (80 m) tall. Spires and other architectural details are included in the height of a building, however, antennas are excluded.

Rank	Name	Image	Location	Height	Floor Count	Year	Use	Notes
1	Centene Plaza C		38°38′57″N 90°20′01″W / 38.64917°N 90.33361°W / 38.64917; -90.33361	419 ft (128 m)	28	2020	Office	Tallest building in Clayton. Headquarters for the Centene Corporation.[2][3]
2	The Plaza in Clayton Residential Tower		38°38′52″N 90°19′56″W / 38.64778°N 90.33222°W / 38.64778; -90.33222	408 ft (124 m)	30	2002	Residential	Tallest residential building in Clayton. Tallest building in Clayton from 2002 to 2020.[4][5]
3	212 South Meramec		38°38′50″N 90°20′23″W / 38.64722°N 90.33972°W / 38.64722; -90.33972	380 ft (116 m)	27	2017	Residential	[6]
4	The Sevens Building		38°38′52″N 90°20′10″W / 38.64778°N 90.33611°W / 38.64778; -90.33611	312 ft (95 m)	24	1969	Office	Tallest building in Clayton from 1969 to 2002.[7][8]
5	Pierre Laclede Center II		38°39′01″N 90°20′08″W / 38.65028°N 90.33556°W / 38.65028; -90.33556	308 ft (94 m)	24	1970	Office	[9][10]
6	101 South Hanley		38°38′53″N 90°20′05″W / 38.64806°N 90.33472°W / 38.64806; -90.33472	272 ft (83 m)	19	1986	Office	[11]
7	Clayton on the Park		38°38′54″N 90°20′29″W / 38.64833°N 90.34139°W / 38.64833; -90.34139	266 ft (81 m)	23	2000	Residential	[12][13]
8	PNC Center		38°38′53″N 90°20′17″W / 38.64806°N 90.33806°W / 38.64806; -90.33806	262 ft (80 m)	18	1973	Office	[14][15]
9	Park Tower		38°38′51″N 90°20′29″W / 38.64750°N 90.34139°W / 38.64750; -90.34139	262 ft (80 m)	24	1966	Residential	Tallest building in Clayton from 1966 to 1969.[16]
10	Centene Plaza B		38°38′59″N 90°20′04″W / 38.64972°N 90.33444°W / 38.64972; -90.33444	262 ft (80 m)	17	2010	Office	[17][18][19]
11	Maryland Walk		38°39′08″N 90°20′26″W / 38.65222°N 90.34056°W / 38.65222; -90.34056	262 ft (80 m)	17	2006	Residential	[20]

There are no buildings in Clayton under construction which stand over 262 ft (80 m).

Name	Image	Years as tallest	Height	Floors	Notes
Park Tower		1966-1969	262 ft (80 m)	24
The Sevens Building		1969-2002	312 ft (95 m)	24
The Plaza in Clayton Residential Tower		2002-2020	408 ft (124 m)	30
Centene Plaza C		2020-Present	419 ft (128 m)	28

• List of tallest buildings in St. Louis
• List of tallest buildings in Kansas City
• List of tallest buildings in Missouri