Pseudooxynicotine oxidase

Pseudooxynicotine oxidase
Identifiers
EC no.1.4.2.3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Pseudooxynicotine oxidase (EC 1.4.2.3) is an enzyme with systematic name 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing).[1] This enzyme catalyses the following chemical reaction

2D representation of the chemical structure of Q27117250.
pseudooxynicotine
+ 2 ferricytochrome c
 
 
H2O
2 H+
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
H2O
2 H+
 
2D representation of the chemical structure of Q27135486.
4-oxo-4-(3-pyridinebutanal)
+ 2 ferrocytochrome c + CH3NH2
 

This enzyme contains one non-covalently bound flavin adenine dinucleotide. It is involved in nicotine breakdown in soil bacteria and releases methylamine.[2]

References

  1. ^ Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W (April 2012). "Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine". Applied and Environmental Microbiology. 78 (7): 2154–60. Bibcode:2012ApEnM..78.2154Q. doi:10.1128/AEM.07025-11. PMC 3302611. PMID 22267672.
  2. ^ Enzyme 1.4.2.3 at KEGG Pathway Database.
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