SW222746

SW222746
Clinical data
Drug class	15-PGDH inhibitor
Identifiers
	IUPAC name 2-methyl-6-[7-(piperidine-1-carbonyl)quinoxalin-2-yl]isoquinolin-1-one;
CAS Number	2241676-74-2;
PubChem CID	135300446;
ChemSpider	128921368;
ChEMBL	ChEMBL5220884;
PDB ligand	RLD (PDBe, RCSB PDB);
Chemical and physical data
Formula	C24H22N4O2
Molar mass	398.466 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1C=CC2=C(C1=O)C=CC(=C2)C3=CN=C4C=CC(=CC4=N3)C(=O)N5CCCCC5;
	InChI InChI=1S/C24H22N4O2/c1-27-12-9-16-13-17(5-7-19(16)24(27)30)22-15-25-20-8-6-18(14-21(20)26-22)23(29)28-10-3-2-4-11-28/h5-9,12-15H,2-4,10-11H2,1H3; Key:URHPFANOQLIROT-UHFFFAOYSA-N;

SW222746 is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). It increases levels of prostaglandin E2 and stimulates tissue regeneration, and has good oral bioavailability.^[1] It has been researched in animal studies for treatment of muscle wasting in the elderly.^[2]^[3]

References

^ Hu B, Toda K, Wang X, Antczak MI, Smith J, Geboers S, et al. (November 2022). "Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration". Journal of Medicinal Chemistry. 65 (22): 15327–15343. doi:10.1021/acs.jmedchem.2c01299. PMC 9885488. PMID 36322935.
^ Huang W, Li H, Kiselar J, Fink SP, Regmi S, Day A, et al. (February 2023). "Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system". Nature Communications. 14 (1) 784. Bibcode:2023NatCo..14..784H. doi:10.1038/s41467-023-36463-7. PMC 9922282. PMID 36774348.
^ Ahmad SS, Lim JH, Choi I, Lee EJ (December 2024). "Biocomputational screening of natural compounds targeting 15-hydroxyprostaglandin dehydrogenase to improve skeletal muscle during aging". Molecular Diversity. 28 (6): 4425–4439. doi:10.1007/s11030-024-10825-9. PMID 38904907.