MLST8
O Subunidade LST8 do complexo alvo da rapamicina, também conhecida como subunidade LST8 do TORC ou semelhante à subunidade beta da proteína G (GβL ou Gable), é uma proteína que em humanos é codificada pelo gene MLST8 (proteína associada a MTOR, homólogo LST8).[2] É uma subunidade de ambos, mTORC1 [en] e mTORC2, complexos que regulam o crescimento e a sobrevivência celular em resposta a sinais de nutrientes, energia, redox e hormonais.[3] É supra-regulada em várias linhagens celulares e tecidos de câncer de cólon e próstata humanos. O knockdown de mLST8 impediu a formação de mTORC e inibiu o crescimento tumoral e a invasividade.[4]
Referências
- ↑ «Human PubMed Reference:»
- ↑ «Entrez Gene: MTOR associated protein»
- ↑ «UniProtKB – Q9BVC4 (LST8_HUMAN)»
- ↑ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 de Abril de 2015). «mLST8 Promotes mTOR-Mediated Tumor Progression». PLOS ONE. 10 (4). Bibcode:2015PLoSO..1019015K. PMC 4408021
. PMID 25906254. doi:10.1371/journal.pone.0119015
Leitura adicional
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- Long X, Lin Y, Ortiz-Vega S, et al. (2005). «Rheb binds and regulates the mTOR kinase.». Curr. Biol. 15 (8): 702–13. Bibcode:2005CBio...15..702L. PMID 15854902. doi:10.1016/j.cub.2005.02.053
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- Kim DH, Sarbassov DD, Ali SM, et al. (2003). «GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.». Mol. Cell. 11 (4): 895–904. PMID 12718876. doi:10.1016/S1097-2765(03)00114-X
- Jacinto E, Loewith R, Schmidt A, et al. (2004). «Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.». Nat. Cell Biol. 6 (11): 1122–8. PMID 15467718. doi:10.1038/ncb1183
- Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). «Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.». Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. PMID 15718470. doi:10.1126/science.1106148