RB1CC1

RB1CC1
Identificadores
Nomes alternativos	RB1CC1
IDs externos	OMIM: 606837 HomoloGene: 7659 GeneCards: RB1CC1
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein kinase binding; • GO:0032947 molecular adaptor activity;
Componente celular	• phagophore assembly site membrane; • envoltório nuclear; • Atg1/ULK1 kinase complex; • phagophore assembly site; • núcleo celular; • citoplasma; • endoplasmic reticulum membrane; • citosol; • extrinsic component of membrane; • lisossoma;
Processo biológico	• positive regulation of protein phosphorylation; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of extrinsic apoptotic signaling pathway; • negative regulation of apoptotic process; • autophagosome assembly; • transcription, DNA-templated; • development of the heart; • positive regulation of cell size; • ciclo celular; • liver development; • macroautophagy; • autofagia; • positive regulation of JNK cascade; • autophagy of mitochondrion; • autophagy of peroxisome; • reticulophagy; • glycophagy; • regulation of macroautophagy; • piecemeal microautophagy of the nucleus;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ;
	Mais dados de referência de expressão
Ortólogos
	9821
	n/a
	ENSG00000023287
	n/a
	Q8TDY2
	n/a
	NM_001083617; NM_014781
	n/a
	NP_001077086; NP_055596
	n/a
	Wikidata
Ver/Editar Humano

A proteína 1 de bobina em espiral induzível por RB1 é uma proteína que em humanos é codificada pelo gene RB1CC1.^[2]^[3]^[4]^[5]

Interações

Demonstrou-se que RB1CC1 interage com PTK2B [en],^[6] ASK1 [en]^[7] e PTK2 [en].^[6]

Referências

↑ «Human PubMed Reference:»
↑ Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Fev 2002). «Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells». Oncogene. 21 (8): 1295–8. PMID 11850849. doi:10.1038/sj.onc.1205171
↑ Maucuer A, Camonis JH, Sobel A (Abr 1995). «Stathmin interaction with a putative kinase and coiled-coil-forming protein domains». Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. Bibcode:1995PNAS...92.3100M. PMC 42112. PMID 7724523. doi:10.1073/pnas.92.8.3100
↑ Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (Maio de 2008). «FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells». The Journal of Cell Biology. 181 (3): 497–510. PMC 2364687. PMID 18443221. doi:10.1083/jcb.200712064
↑ «Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1»
1 2 Ueda H, Abbi S, Zheng C, Guan JL (Abr 2000). «Suppression of Pyk2 kinase and cellular activities by FIP200». The Journal of Cell Biology. 149 (2): 423–30. PMC 2175150. PMID 10769033. doi:10.1083/jcb.149.2.423
↑ Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Out 2006). «Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways». The Journal of Cell Biology. 175 (1): 121–33. PMC 2064504. PMID 17015619. doi:10.1083/jcb.200604129

Leitura adicional

Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Out 1996). «Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain». DNA Research. 3 (5): 321–9, 341–54. PMID 9039502. doi:10.1093/dnares/3.5.321
Ueda H, Abbi S, Zheng C, Guan JL (Abr 2000). «Suppression of Pyk2 kinase and cellular activities by FIP200». The Journal of Cell Biology. 149 (2): 423–30. PMC 2175150. PMID 10769033. doi:10.1083/jcb.149.2.423
Chano T, Kontani K, Teramoto K, Okabe H, Ikegawa S (julho de 2002). «Truncating mutations of RB1CC1 in human breast cancer». Nature Genetics. 31 (3): 285–8. PMID 12068296. doi:10.1038/ng911
Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H (Maio de 2002). «Isolation, characterization and mapping of the mouse and human RB1CC1 genes». Gene. 291 (1–2): 29–34. PMID 12095676. doi:10.1016/S0378-1119(02)00585-1
Chano T, Saeki Y, Serra M, Matsumoto K, Okabe H (Ago 2002). «Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells». The American Journal of Pathology. 161 (2): 359–64. PMC 1850752. PMID 12163359. doi:10.1016/S0002-9440(10)64190-9
Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL (Set 2002). «Regulation of focal adhesion kinase by a novel protein inhibitor FIP200». Molecular Biology of the Cell. 13 (9): 3178–91. PMC 124151. PMID 12221124. doi:10.1091/mbc.E02-05-0295
Kontani K, Chano T, Ozaki Y, Tezuka N, Sawai S, Fujino S, Saeki Y, Okabe H (novembro de 2003). «RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells». International Journal of Molecular Medicine. 12 (5): 767–9. PMID 14533007. doi:10.3892/ijmm.12.5.767
Bamba N, Chano T, Taga T, Ohta S, Takeuchi Y, Okabe H (Out 2004). «Expression and regulation of RB1CC1 in developing murine and human tissues». International Journal of Molecular Medicine. 14 (4): 583–7. PMID 15375585. doi:10.3892/ijmm.14.4.583
Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H (Set 2005). «Rb1cc1 is critical for myoblast differentiation through Rb1 regulation». Virchows Archiv. 447 (3): 643–8. PMID 15968549. doi:10.1007/s00428-004-1183-1
Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL (Ago 2005). «Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control». The Journal of Cell Biology. 170 (3): 379–89. PMC 2171462. PMID 16043512. doi:10.1083/jcb.200411106
Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL (Ago 2005). «Mechanism of cell cycle regulation by FIP200 in human breast cancer cells». Cancer Research. 65 (15): 6676–84. PMID 16061648. doi:10.1158/0008-5472.CAN-04-4142
Chano T, Saji M, Inoue H, Minami K, Kobayashi T, Hino O, Okabe H (Set 2006). «Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation». International Journal of Molecular Medicine. 18 (3): 425–32. PMID 16865226. doi:10.3892/ijmm.18.3.425
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembro de 2006). «Global, in vivo, and site-specific phosphorylation dynamics in signaling networks». Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Molecular Systems Biology. 3 (1). 89 páginas. PMC 1847948. PMID 17353931. doi:10.1038/msb4100134
Lee YC, Yang VC, Wang TS (Set 2007). «Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells». Toxicology. 239 (1–2): 108–15. PMID 17707572. doi:10.1016/j.tox.2007.06.101

[1] «Human PubMed Reference:»

[pmid11850849-2] Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Fev 2002). «Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells». Oncogene. 21 (8): 1295–8. PMID 11850849. doi:10.1038/sj.onc.1205171

[pmid7724523-3] Maucuer A, Camonis JH, Sobel A (Abr 1995). «Stathmin interaction with a putative kinase and coiled-coil-forming protein domains». Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. Bibcode:1995PNAS...92.3100M. PMC 42112. PMID 7724523. doi:10.1073/pnas.92.8.3100

[pmid18443221-4] Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (Maio de 2008). «FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells». The Journal of Cell Biology. 181 (3): 497–510. PMC 2364687. PMID 18443221. doi:10.1083/jcb.200712064

[entrez-5] «Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1»

[pmid10769033-6] 1 2 Ueda H, Abbi S, Zheng C, Guan JL (Abr 2000). «Suppression of Pyk2 kinase and cellular activities by FIP200». The Journal of Cell Biology. 149 (2): 423–30. PMC 2175150. PMID 10769033. doi:10.1083/jcb.149.2.423

[pmid17015619-7] Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Out 2006). «Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways». The Journal of Cell Biology. 175 (1): 121–33. PMC 2064504. PMID 17015619. doi:10.1083/jcb.200604129

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