RFC1

Фактор репликации C (активатор 1) 1, 145kDa
Фактор репликации C (активатор 1) 1, 145kDa
	Представлено на основе PDB 2EBU.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 2EBU, 2K6G, 2K7F
Идентификаторы
Символ	RFC1 ; A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
Внешние ID	OMIM: 102579 MGI: 97891 HomoloGene: 2187 GeneCards: Ген RFC1
Функция	• DNA binding; • DNA clamp loader activity; • double-stranded DNA binding; • protein binding; • ATP binding; • enzyme activator activity; • protein domain specific binding; • sequence-specific DNA binding;
Компонент клетки	• nucleus; • nucleoplasm; • DNA replication factor C complex; • nucleolus; • Golgi apparatus; • cell junction; • extracellular vesicular exosome;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • mitotic cell cycle; • telomere maintenance via recombination; • telomere maintenance; • ATP catabolic process; • DNA-dependent DNA replication; • DNA strand elongation involved in DNA replication; • DNA repair; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair; • nucleotide-excision repair, DNA gap filling; • transcription, DNA-templated; • telomere maintenance via telomerase; • telomere maintenance via semi-conservative replication; • positive regulation of catalytic activity; • positive regulation of transcription, DNA-templated;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Фактор репликации С субъединица 1 — белок, кодируемый у человека геном RFC1 . ^[1]^[2]

Функция

Белок, кодируемый этим геном является большой субъединицей фактора репликации С, который является субъединицей пяти аксессуарных белков ДНК-полимеразы. Фактор репликации С является ДНК-зависимой АТФазой, что требуется для эукариотической репликации и репарации ДНК. Белок действует в качестве активатора ДНК-полимераз, связывается с 3'-концами праймеров, а также способствует скоординированному синтезу обеих нитей. Он также может играть определенную роль в стабильности теломеров. ^[2]

Взаимодействия

RFC1, как было выявлено, взаимодействует с:

BRD4, ^[3]
HDAC1, ^[4]
PCNA, ^[3]^[5]^[6]^[7]^[8]
РЕЛА ^[9] и
RFC3. ^[10]^[11]^[12]

Примечания

↑ Luckow B., Bunz F., Stillman B., Lichter P., Schütz G. Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans (англ.) // Molecular and Cellular Biology : journal. — 1994. — March (vol. 14, no. 3). — P. 1626—1634. — PMID 8114700. — PMC 358521.
↑ ¹ ² Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa .
↑ ¹ ² Maruyama T., Farina A., Dey A., Cheong J., Bermudez V.P., Tamura T., Sciortino S., Shuman J., Hurwitz J., Ozato K. A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase (англ.) // Molecular and Cellular Biology : journal. — 2002. — September (vol. 22, no. 18). — P. 6509—6520. — doi:10.1128/mcb.22.18.6509-6520.2002. — PMID 12192049. — PMC 135621.
↑ Anderson L.A., Perkins N.D. The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 (англ.) // Journal of Biological Chemistry : journal. — 2002. — August (vol. 277, no. 33). — P. 29550—29554. — doi:10.1074/jbc.M200513200. — PMID 12045192.
↑ Fotedar R., Mossi R., Fitzgerald P., Rousselle T., Maga G., Brickner H., Messier H., Kasibhatla S., Hübscher U., Fotedar A. A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells (англ.) // The EMBO Journal : journal. — 1996. — August (vol. 15, no. 16). — P. 4423—4433. — PMID 8861969. — PMC 452166.
↑ Mossi R., Jónsson Z.O., Allen B.L., Hardin S.H., Hübscher U. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen (англ.) // Journal of Biological Chemistry : journal. — 1997. — January (vol. 272, no. 3). — P. 1769—1776. — doi:10.1074/jbc.272.3.1769. — PMID 8999859.
↑ van der Kuip H., Carius B., Haque S.J., Williams B.R., Huber C., Fischer T. The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins (англ.) // Journal of Molecular Medicine : journal. — 1999. — April (vol. 77, no. 4). — P. 386—392. — doi:10.1007/s001090050365. — PMID 10353443.
↑ Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein (англ.) // Journal of Biological Chemistry : journal. — 2002. — October (vol. 277, no. 43). — P. 40362—40367. — doi:10.1074/jbc.M206194200. — PMID 12171929.
↑ Anderson L.A., Perkins N.D. Regulation of RelA (p65) function by the large subunit of replication factor C (англ.) // Molecular and Cellular Biology : journal. — 2003. — January (vol. 23, no. 2). — P. 721—732. — doi:10.1128/mcb.23.2.721-732.2003. — PMID 12509469. — PMC 151544.
↑ Ellison V., Stillman B. Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity (англ.) // Journal of Biological Chemistry : journal. — 1998. — March (vol. 273, no. 10). — P. 5979—5987. — doi:10.1074/jbc.273.10.5979. — PMID 9488738.
↑ Uhlmann F., Cai J., Flores-Rozas H., Dean F.B., Finkelstein J., O'Donnell M., Hurwitz J. In vitro reconstitution of human replication factor C from its five subunits (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — June (vol. 93, no. 13). — P. 6521—6526. — doi:10.1073/pnas.93.13.6521. — PMID 8692848. — PMC 39056.
↑ Tomida J., Masuda Y., Hiroaki H., Ishikawa T., Song I., Tsurimoto T., Tateishi S., Shiomi T., Kamei Y., Kim J., Kamiya K., Vaziri C., Ohmori H., Todo T. DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex (англ.) // Journal of Biological Chemistry : journal. — 2008. — April (vol. 283, no. 14). — P. 9071—9079. — doi:10.1074/jbc.M709835200. — PMID 18245774. — PMC 2431014.

Литература

Lu Y., Riegel A.T. The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA (англ.) // Gene : journal. — Elsevier, 1994. — Vol. 145, no. 2. — P. 261—265. — doi:10.1016/0378-1119(94)90017-5. — PMID 7914507.
Bunz F., Kobayashi R., Stillman B. cDNAs encoding the large subunit of human replication factor C (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1994. — Vol. 90, no. 23. — P. 11014—11018. — doi:10.1073/pnas.90.23.11014. — PMID 8248204. — PMC 47912.
Lu Y., Zeft A.S., Riegel A.T. Cloning and expression of a novel human DNA binding protein, PO-GA (англ.) // Biochemical and Biophysical Research Communications : journal. — 1993. — Vol. 193, no. 2. — P. 779—786. — doi:10.1006/bbrc.1993.1693. — PMID 8512577.
Uhlmann F., Cai J., Flores-Rozas H., Dean F.B., Finkelstein J., O'Donnell M., Hurwitz J. In vitro reconstitution of human replication factor C from its five subunits (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — Vol. 93, no. 13. — P. 6521—6526. — doi:10.1073/pnas.93.13.6521. — PMID 8692848. — PMC 39056.
Fotedar R., Mossi R., Fitzgerald P., Rousselle T., Maga G., Brickner H., Messier H., Kasibhatla S., Hübscher U., Fotedar A. A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells (англ.) // The EMBO Journal : journal. — 1996. — Vol. 15, no. 16. — P. 4423—4433. — PMID 8861969. — PMC 452166.
Uchiumi F., Ohta T., Tanuma S. Replication factor C recognizes 5'-phosphate ends of telomeres (англ.) // Biochemical and Biophysical Research Communications : journal. — 1997. — Vol. 229, no. 1. — P. 310—315. — doi:10.1006/bbrc.1996.1798. — PMID 8954124.
Mossi R., Jónsson Z.O., Allen B.L., Hardin S.H., Hübscher U. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen (англ.) // Journal of Biological Chemistry : journal. — 1997. — Vol. 272, no. 3. — P. 1769—1776. — doi:10.1074/jbc.272.3.1769. — PMID 8999859.
Cujec T.P., Cho H., Maldonado E., Meyer J., Reinberg D., Peterlin B.M. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme (англ.) // Molecular and Cellular Biology : journal. — 1997. — Vol. 17, no. 4. — P. 1817—1823. — PMID 9121429. — PMC 232028.
Ubeda M., Habener J.F. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis (англ.) // Journal of Biological Chemistry : journal. — 1997. — Vol. 272, no. 31. — P. 19562—19568. — doi:10.1074/jbc.272.31.19562. — PMID 9235961.
Rhéaume E., Cohen L.Y., Uhlmann F., Lazure C., Alam A., Hurwitz J., Sékaly R.P., Denis F. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis (англ.) // The EMBO Journal : journal. — 1998. — Vol. 16, no. 21. — P. 6346—6354. — doi:10.1093/emboj/16.21.6346. — PMID 9351817. — PMC 1170241.
Ellison V., Stillman B. Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity (англ.) // Journal of Biological Chemistry : journal. — 1998. — Vol. 273, no. 10. — P. 5979—5987. — doi:10.1074/jbc.273.10.5979. — PMID 9488738.
Coll J.M., Hickey R.J., Cronkey E.A., Jiang H.Y., Schnaper L., Lee M.Y., Uitto L., Syvaoja J.E., Malkas L.H. Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome (англ.) // Oncol. Res. : journal. — 1998. — Vol. 9, no. 11—12. — P. 629—639. — PMID 9563011.
Allen B.L., Uhlmann F., Gaur L.K., Mulder B.A., Posey K.L., Jones L.B., Hardin S.H. DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C (англ.) // Nucleic Acids Research : journal. — 1998. — Vol. 26, no. 17. — P. 3877—3882. — doi:10.1093/nar/26.17.3877. — PMID 9705493. — PMC 147807.
van der Kuip H., Carius B., Haque S.J., Williams B.R., Huber C., Fischer T. The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins (англ.) // Journal of Molecular Medicine : journal. — 1999. — Vol. 77, no. 4. — P. 386—392. — doi:10.1007/s001090050365. — PMID 10353443.
Wang Y., Cortez D., Yazdi P., Neff N., Elledge S.J., Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures (англ.) // Genes & Development : journal. — 2000. — Vol. 14, no. 8. — P. 927—939. — PMID 10783165. — PMC 316544.
Yazdi P.T., Wang Y., Zhao S., Patel N., Lee E.Y., Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint (англ.) // Genes & Development : journal. — 2002. — Vol. 16, no. 5. — P. 571—582. — doi:10.1101/gad.970702. — PMID 11877377. — PMC 155356.
Anderson L.A., Perkins N.D. The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 (англ.) // Journal of Biological Chemistry : journal. — 2002. — Vol. 277, no. 33. — P. 29550—29554. — doi:10.1074/jbc.M200513200. — PMID 12045192.
Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein (англ.) // Journal of Biological Chemistry : journal. — 2002. — Vol. 277, no. 43. — P. 40362—40367. — doi:10.1074/jbc.M206194200. — PMID 12171929.
Maruyama T., Farina A., Dey A., Cheong J., Bermudez V.P., Tamura T., Sciortino S., Shuman J., Hurwitz J., Ozato K. A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase (англ.) // Molecular and Cellular Biology : journal. — 2002. — Vol. 22, no. 18. — P. 6509—6520. — doi:10.1128/MCB.22.18.6509-6520.2002. — PMID 12192049. — PMC 135621.

[pmid8114700-1] Luckow B., Bunz F., Stillman B., Lichter P., Schütz G. Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans (англ.) // Molecular and Cellular Biology : journal. — 1994. — March (vol. 14, no. 3). — P. 1626—1634. — PMID 8114700. — PMC 358521.

[entrez-2] ¹ ² Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa .

[pmid12192049-3] ¹ ² Maruyama T., Farina A., Dey A., Cheong J., Bermudez V.P., Tamura T., Sciortino S., Shuman J., Hurwitz J., Ozato K. A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase (англ.) // Molecular and Cellular Biology : journal. — 2002. — September (vol. 22, no. 18). — P. 6509—6520. — doi:10.1128/mcb.22.18.6509-6520.2002. — PMID 12192049. — PMC 135621.

[pmid12045192-4] Anderson L.A., Perkins N.D. The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 (англ.) // Journal of Biological Chemistry : journal. — 2002. — August (vol. 277, no. 33). — P. 29550—29554. — doi:10.1074/jbc.M200513200. — PMID 12045192.

[pmid8861969-5] Fotedar R., Mossi R., Fitzgerald P., Rousselle T., Maga G., Brickner H., Messier H., Kasibhatla S., Hübscher U., Fotedar A. A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells (англ.) // The EMBO Journal : journal. — 1996. — August (vol. 15, no. 16). — P. 4423—4433. — PMID 8861969. — PMC 452166.

[pmid8999859-6] Mossi R., Jónsson Z.O., Allen B.L., Hardin S.H., Hübscher U. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen (англ.) // Journal of Biological Chemistry : journal. — 1997. — January (vol. 272, no. 3). — P. 1769—1776. — doi:10.1074/jbc.272.3.1769. — PMID 8999859.

[pmid10353443-7] van der Kuip H., Carius B., Haque S.J., Williams B.R., Huber C., Fischer T. The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins (англ.) // Journal of Molecular Medicine : journal. — 1999. — April (vol. 77, no. 4). — P. 386—392. — doi:10.1007/s001090050365. — PMID 10353443.

[pmid12171929-8] Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein (англ.) // Journal of Biological Chemistry : journal. — 2002. — October (vol. 277, no. 43). — P. 40362—40367. — doi:10.1074/jbc.M206194200. — PMID 12171929.

[pmid12509469-9] Anderson L.A., Perkins N.D. Regulation of RelA (p65) function by the large subunit of replication factor C (англ.) // Molecular and Cellular Biology : journal. — 2003. — January (vol. 23, no. 2). — P. 721—732. — doi:10.1128/mcb.23.2.721-732.2003. — PMID 12509469. — PMC 151544.

[pmid9488738-10] Ellison V., Stillman B. Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity (англ.) // Journal of Biological Chemistry : journal. — 1998. — March (vol. 273, no. 10). — P. 5979—5987. — doi:10.1074/jbc.273.10.5979. — PMID 9488738.

[pmid8692848-11] Uhlmann F., Cai J., Flores-Rozas H., Dean F.B., Finkelstein J., O'Donnell M., Hurwitz J. In vitro reconstitution of human replication factor C from its five subunits (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — June (vol. 93, no. 13). — P. 6521—6526. — doi:10.1073/pnas.93.13.6521. — PMID 8692848. — PMC 39056.

[pmid18245774-12] Tomida J., Masuda Y., Hiroaki H., Ishikawa T., Song I., Tsurimoto T., Tateishi S., Shiomi T., Kamei Y., Kim J., Kamiya K., Vaziri C., Ohmori H., Todo T. DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex (англ.) // Journal of Biological Chemistry : journal. — 2008. — April (vol. 283, no. 14). — P. 9071—9079. — doi:10.1074/jbc.M709835200. — PMID 18245774. — PMC 2431014.

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