PEA15

PEA15
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	4IZ5, 4IZA, 1N3K,%%s1N3K
Identificadores
Alias	PEA15, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15, PED-PED/proliferation and apoptosis adaptor protein 15
IDs externos	OMIM: 603434 MGI: 104799 HomoloGene: 7884 GeneCards: PEA15
Ontología génica
Función molecular	• GO:0001948, GO:0016582 unión a proteína plasmática;
Componente celular	• citoplasma; • microtubule associated complex; • núcleo celular; • citosol;
Proceso biológico	• MAPK cascade; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • regulation of apoptotic process; • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of glucose import; • GO:0097285 apoptosis; • GO:0006859 transporte de carbohidratos; • DNA damage checkpoint signaling; • response to morphine;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	; ;
	Más referencias a datos de expressión
Ortólogos
	8682
	18611
	ENSG00000162734
	ENSMUSG00000013698
	Q15121
	Q62048
	NM_001297576; NM_001297577; NM_001297578; NM_003768
	NM_011063; NM_001329869; NM_001329871; NM_008556
NP_001284505; NP_001284506; NP_001284507; NP_003759; NP_001284506.1;
	NP_003759.1
	NP_001316798; NP_001316800; NP_035193
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La fosfoproteína astrocítica 15 (PEA15) proteína adaptadora de proliferación y apoptosis 15, variante de transcripción 5 es una proteína codificada en humanos por el gen pea15.^[3]^[4]

La proteína PEA15 contiene un dominio efector de muerte (DED) y se expresa de forma predominante en el sistema nervioso central, particularmente en astrocitos.^[4]

Sinónimos

HMAT1
MAT1
PED
PEA-15
MAT1H
HUMMAT1H
PED-PEA15
PED/PEA15

Alias

Fosfoproteína enriquecida en astrocitos, 15 kD
homólogo del oncogén MAT-1 de ratón
Fosfoproteína enriquecida en la diabetes

Interacciones

La proteína PEA15 ha demostrado ser capaz de interaccionar con:

Fosfolipasa D1^[5]
Caspasa 8^[6]^[7]
MAPK1^[8]
FADD^[6]^[7]
RPS6KA3^[9]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (Sep de 1997). «Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers». Genomics 42 (3): 540-2. PMID 9205133.
1 2 «Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15».
↑ Zhang, Y; Redina O, Altshuller Y M, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman M A (Nov. de 2000). «Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them». J. Biol. Chem. (UNITED STATES) 275 (45): 35224-32. ISSN 0021-9258. PMID 10926929. doi:10.1074/jbc.M003329200.
1 2 Kitsberg, D; Formstecher E; Fauquet M; Kubes M; Cordier J; Canton B; Pan G; Rolli M; Glowinski J; Chneiweiss H (Oct. de 1999). «Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis». J. Neurosci. (UNITED STATES) 19 (19): 8244-51. PMID 10493725.
1 2 Condorelli, G; Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (Aug. de 1999). «PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis». Oncogene (ENGLAND) 18 (31): 4409-15. ISSN 0950-9232. PMID 10442631. doi:10.1038/sj.onc.1202831.
↑ Formstecher, E; Ramos J W, Fauquet M, Calderwood D A, Hsieh J C, Canton B, Nguyen X T, Barnier J V, Camonis J, Ginsberg M H, Chneiweiss H (Aug. de 2001). «PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase». Dev. Cell (United States) 1 (2): 239-50. ISSN 1534-5807. PMID 11702783.
↑ Vaidyanathan, Hema; Ramos Joe W (Aug. de 2003). «RSK2 activity is regulated by its interaction with PEA-15». J. Biol. Chem. (United States) 278 (34): 32367-72. ISSN 0021-9258. PMID 12796492. doi:10.1074/jbc.M303988200.

Enlaces externos

En HomoloGene: PEA15

En Genome:PEA15
En MalaCards.Enfermedades que coinciden con:PEA15

Busca fuentes: «PEA15» – noticias · libros · académico · imágenes

Datos: Q18033211

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid9205133-3] Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (Sep de 1997). «Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers». Genomics 42 (3): 540-2. PMID 9205133.

[entrez-4] 1 2 «Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15».

[pmid10926929-5] Zhang, Y; Redina O, Altshuller Y M, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman M A (Nov. de 2000). «Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them». J. Biol. Chem. (UNITED STATES) 275 (45): 35224-32. ISSN 0021-9258. PMID 10926929. doi:10.1074/jbc.M003329200.

[pmid10493725-6] 1 2 Kitsberg, D; Formstecher E; Fauquet M; Kubes M; Cordier J; Canton B; Pan G; Rolli M; Glowinski J; Chneiweiss H (Oct. de 1999). «Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis». J. Neurosci. (UNITED STATES) 19 (19): 8244-51. PMID 10493725.

[pmid10442631-7] 1 2 Condorelli, G; Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (Aug. de 1999). «PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis». Oncogene (ENGLAND) 18 (31): 4409-15. ISSN 0950-9232. PMID 10442631. doi:10.1038/sj.onc.1202831.

[pmid11702783-8] Formstecher, E; Ramos J W, Fauquet M, Calderwood D A, Hsieh J C, Canton B, Nguyen X T, Barnier J V, Camonis J, Ginsberg M H, Chneiweiss H (Aug. de 2001). «PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase». Dev. Cell (United States) 1 (2): 239-50. ISSN 1534-5807. PMID 11702783.

[pmid12796492-9] Vaidyanathan, Hema; Ramos Joe W (Aug. de 2003). «RSK2 activity is regulated by its interaction with PEA-15». J. Biol. Chem. (United States) 278 (34): 32367-72. ISSN 0021-9258. PMID 12796492. doi:10.1074/jbc.M303988200.

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