RALGDS

RALGDS
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	1RAX, 2B3A, 2RGF, 3KH0
Identificadores
Alias	RALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
IDs externos	OMIM: 601619 MGI: 107485 HomoloGene: 4562 GeneCards: RALGDS
Ontología génica
Función molecular	• GO:0001948, GO:0016582 unión a proteína plasmática; • guanyl-nucleotide exchange factor activity; • GO:0005083 GTPase regulator activity;
Componente celular	• citosol; • borde en cepillo; • citoplasma; • núcleo celular;
Proceso biológico	• small GTPase mediated signal transduction; • Ras protein signal transduction; • GO:0072468 transducción de señal; • GO:0048552 regulation of catalytic activity;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	; ;
	Más referencias a datos de expressión
Ortólogos
	5900
	19730
	ENSG00000160271
	ENSMUSG00000026821
	Q12967
	Q03385
	NM_006266; NM_001042368; NM_001271774; NM_001271775; NM_001271776
	NM_001145834; NM_001145835; NM_001145836; NM_009058
	NP_001035827; NP_001258703; NP_001258704; NP_001258705; NP_006257
	NP_001139306; NP_001139307; NP_001139308; NP_033084
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

Estimulador de disociación de nucleótidos de guanina ral (RALGDS) es una proteína que en los humanos está codificado por el gen RALGDS.^[3]^[4]

Interacciones

RALGDS ha sido mostrado para interaccionar con:

Arrestin beta 1,^[5]
Arrestin beta 2,^[5]
HRAS,^[3]^[6]^[7]^[8]^[9]^[10]^[11]^[12]
KRAS,^[6]^[8]
MRAS,^[13]^[14]
RAP1A,^[7]^[15]
RAP2A,^[15]
RAPGEF2,^[6] y
RRAS.^[6]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
1 2 «Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator». Proc Natl Acad Sci U S A 91 (23): 11089-93. December 1994. PMC 45172. PMID 7972015. doi:10.1073/pnas.91.23.11089.
↑ «Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator».
1 2 Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). «Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization». Nat. Cell Biol. 4 (8): 547-55. PMID 12105416.
1 2 3 4 Spaargaren M, Bischoff JR (Diciembre de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMC 45488. PMID 7809086.
1 2 Boettner B, Govek EE, Cross J, Van Aelst L (Agosto de 2000). «The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin». Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064-9. PMC 16822. PMID 10922060.
1 2 Li W, Han M, Guan KL (Abril de 2000). «The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf». Genes Dev. 14 (8): 895-900. PMC 316541. PMID 10783161.
↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (Mayo de 2004). «Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization». J. Biol. Chem. 279 (21): 22353-61. PMID 15031288.
↑ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (Febrero de 1997). «RalGDS functions in Ras- and cAMP-mediated growth stimulation». J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.
↑ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (Mayo de 1997). «Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras». Cell 89 (3): 457-67. PMID 9150145.
↑ Stang S, Bottorff D, Stone JC (Junio de 1997). «Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells». Mol. Cell. Biol. 17 (6): 3047-55. PMC 232157. PMID 9154803.
↑ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Noviembre de 1997). «Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution». Oncogene 15 (22): 2675-85. PMID 9400994.
↑ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (Octubre de 1999). «M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line». Blood 94 (7): 2433-44. PMID 10498616.
1 2 Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Marzo de 1999). «Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2». J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.

Enlaces externos

En Genome:RALGDS
En MalaCards.Enfermedades que coinciden con:RALGDS
En Estudio de asociación del genoma completo (GWAS) RALGDS
RALGDS En Disease. Asociaciones entre enfermedades y genes extraídas de la literatura

Esta obra contiene una traducción derivada de «RALGDS» de Wikipedia en inglés, publicada por sus editores bajo la Licencia de documentación libre de GNU y la Licencia Creative Commons Atribución-CompartirIgual 4.0 Internacional.

Datos: Q18031027

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid7972015-3] 1 2 «Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator». Proc Natl Acad Sci U S A 91 (23): 11089-93. December 1994. PMC 45172. PMID 7972015. doi:10.1073/pnas.91.23.11089.

[entrez-4] «Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator».

[pmid12105416-5] 1 2 Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). «Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization». Nat. Cell Biol. 4 (8): 547-55. PMID 12105416.

[pmid7809086-6] 1 2 3 4 Spaargaren M, Bischoff JR (Diciembre de 1994). «Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap». Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. PMC 45488. PMID 7809086.

[pmid10922060-7] 1 2 Boettner B, Govek EE, Cross J, Van Aelst L (Agosto de 2000). «The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin». Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064-9. PMC 16822. PMID 10922060.

[pmid10783161-8] 1 2 Li W, Han M, Guan KL (Abril de 2000). «The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf». Genes Dev. 14 (8): 895-900. PMC 316541. PMID 10783161.

[pmid15031288-9] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (Mayo de 2004). «Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization». J. Biol. Chem. 279 (21): 22353-61. PMID 15031288.

[pmid9038168-10] Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (Febrero de 1997). «RalGDS functions in Ras- and cAMP-mediated growth stimulation». J. Biol. Chem. 272 (9): 5600-5. PMID 9038168.

[pmid9150145-11] Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (Mayo de 1997). «Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras». Cell 89 (3): 457-67. PMID 9150145.

[pmid9154803-12] Stang S, Bottorff D, Stone JC (Junio de 1997). «Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells». Mol. Cell. Biol. 17 (6): 3047-55. PMC 232157. PMID 9154803.

[pmid9400994-13] Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Noviembre de 1997). «Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution». Oncogene 15 (22): 2675-85. PMID 9400994.

[pmid10498616-14] Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (Octubre de 1999). «M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line». Blood 94 (7): 2433-44. PMID 10498616.

[pmid10085114-15] 1 2 Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Marzo de 1999). «Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2». J. Biol. Chem. 274 (13): 8737-45. PMID 10085114.

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