ZMPSTE24

ZMPSTE24
Structures disponibles PDB Recherche d'orthologue : PDBe RCSB Identifiants PDB 2YPT, 4AW6
Identifiants
Alias	ZMPSTE24
IDs externes	OMIM: 606480 MGI: 1890508 HomoloGene: 4277 GeneCards: ZMPSTE24
Nomenclature EC	3.4.24.84
Position du gène (humain) Chr. Chromosome 1 humain[1] Locus 1p34.2 Début 40,258,041 bp[1] Fin 40,294,180 bp[1]
Position du gène (souris) Chr. Chromosome 4 (souris)[2] Locus 4|4 D2.2 Début 120,916,434 bp[2] Fin 120,955,438 bp[2]
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans follicule pileux Epithelium of choroid plexus tubule rénal tibia germinal epithelium mucosa of ileum mucosa of sigmoid colon ventricule droit gingival epithelium îlot de Langerhans Fortement exprimé dans vestibular membrane of cochlear duct saccule artère carotide externe artère carotide interne Vesicula otica Epithelium of choroid plexus otic placode endothelial cell of lymphatic vessel corpuscule carotidien morula Plus de données d'expression de référence BioGPS n/a
Gene Ontology Fonction moléculaire activité peptidasique metalloexopeptidase activity activité hydrolase metallopeptidase activity liaison ion métal metalloendopeptidase activity liaison protéique double-stranded DNA binding endopeptidase activity Composant cellulaire integral component of membrane nuclear inner membrane exosome membrane du réticulum endoplasmique réticulum endoplasmique membrane noyau integral component of endoplasmic reticulum membrane enveloppe nucléaire complexe macromoléculaire Processus biologique prenylated protein catabolic process organisation de l'enveloppe nucléaire protéolyse CAAX-box protein processing liver development hair follicle development heart morphogenesis ventricular cardiac muscle tissue development cardiac ventricle development growth plate cartilage development réparation de l'ADN organisation de la chromatine regulation of transcription, DNA-templated inflammatory cell apoptotic process cellular response to DNA damage stimulus organisation d'un noyau regulation of mitotic cell cycle adult walking behavior regulation of heart contraction determination of adult lifespan regulation of cell shape epidermis development regulation of autophagy positive regulation of gene expression negative regulation of gene expression regulation of glucose metabolic process protein processing regulation of lipid metabolic process minéralisation osseuse regulation of bone mineralization regulation of TOR signaling regulation of hormone metabolic process multicellular organism growth regulation of multicellular organism growth maintenance of rDNA regulation of DNA damage response, signal transduction by p53 class mediator histone H2B acetylation histone H2B-K5 acetylation hypomethylation of CpG island regulation of DNA methylation processus métabolique lipidique cellulaire regulation of fibroblast proliferation thymus development regulation of defense response to virus neuromuscular process organisation des chromosomes regulation of ventricular cardiac muscle cell membrane repolarization kidney morphogenesis cardiac conduction CAMKK-AMPK signaling cascade regulation of stress-activated protein kinase signaling cascade cellular response to gamma radiation response to DNA damage checkpoint signaling regulation of histone H4 acetylation regulation of RNA polymerase II regulatory region sequence-specific DNA binding regulation of mitotic cell cycle DNA replication regulation of blood circulation negative regulation of production of miRNAs involved in gene silencing by miRNA calcium ion import into sarcoplasmic reticulum regulation of histone H4-K16 acetylation regulation of termination of RNA polymerase I transcription regulation of cellular senescence Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 10269 230709 Ensembl ENSG00000084073 ENSMUSG00000043207 UniProt O75844 Q80W54 RefSeq (mRNA) NM_005857 NM_172700 RefSeq (protéine) NP_005848 NP_766288 Localisation (UCSC) Chr 1: 40.26 – 40.29 Mb Chr 4: 120.92 – 120.96 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris

ZMPSTE24 est un gène situé sur le chromosome 1 humain^[5].

• Dysplasie mandibulo-acrale avec lipodystrophie de type B^[6]
• Progéria
• Dermopathie restrictive

• Portail de la biologie cellulaire et moléculaire
• Portail de la médecine