FGIN-127

FGIN-127
識別子
	IUPAC名 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide;
CAS登録番号	142720-24-9 ;
PubChem; CID	132496;
ChemSpider	116994 ;
ChEBI	CHEBI:92171 ;
CompTox; Dashboard; (EPA)	DTXSID90162141 ;
化学的および物理的データ
化学式	C28H37FN2O
分子量	436.615 g·mol−1
3D model; (JSmol)	Interactive image;
	SMILES CCCCCCN(CCCCCC)C(=O)Cc1c2ccccc2[nH]c1c3ccc(cc3)F;
	InChI InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3 ; Key:VUWXAQFLTSBUDB-UHFFFAOYSA-N ;
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FGIN-127は、ミトコンドリア18 kDaトランスポータータンパク質またはTSPOとしても知られる末梢ベンゾジアゼピン受容体における選択的アゴニストとして作用する抗不安薬である。アロプレグナノロンなどの神経ステロイドの生成を刺激することで抗不安作用を示すと考えられている^[1]^[2]^[3]^[4]^[5]^[6]。

脚注

↑ “2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)”. The Journal of Pharmacology and Experimental Therapeutics 262 (3): 971–8. (September 1992). PMID 1326631.
↑ “Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex”. The Journal of Pharmacology and Experimental Therapeutics 267 (1): 462–71. (October 1993). PMID 8229777.
↑ “Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43”. The Journal of Pharmacy and Pharmacology 53 (11): 1561–8. (November 2001). doi:10.1211/0022357011777945. PMID 11732760.
↑ “In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters”. Psychopharmacology 178 (2–3): 174–82. (March 2005). doi:10.1007/s00213-004-2001-9. PMID 15338106.
↑ “Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27”. Organic Letters 8 (20): 4473–5. (September 2006). doi:10.1021/ol061617+. PMID 16986928.
↑ “Development of ligands for the peripheral benzodiazepine receptor”. Current Medicinal Chemistry 13 (17): 1991–2001. (2006). doi:10.2174/092986706777584979. hdl:2158/222808. PMID 16842193.