GJA5

GJA5
معرفات
أسماء بديلة	GJA5, ATFB11, CX40, gap junction protein alpha 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 121013 MGI: MGI:95716 HomoloGene: 3856 GeneCards: 2702
علم الوجود الجيني
وظائف جزيئية	• gap junction channel activity involved in cardiac conduction electrical coupling; • gap junction channel activity; • gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; • gap junction hemi-channel activity; • gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling; • gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling; • gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling; • gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling; • disordered domain specific binding; • connexin binding;
مكونات خلوية	• مكون تكاملي للغشاء; • إسقاط خلية; • غشاء; • intercalated disc; • غشاء خلوي; • integral component of plasma membrane; • موصل خلوي; • تقاطعات الفجوة بين الخلايا; • كونيكسون;
عمليات حيوية	• bundle of His cell to Purkinje myocyte communication by electrical coupling; • skeletal system development; • regulation of ventricular cardiac muscle cell membrane depolarization; • cardiac conduction system development; • ventricular septum development; • negative regulation of blood pressure; • ventricular septum morphogenesis; • SA node cell action potential; • AV node cell to bundle of His cell communication; • regulation of atrial cardiac muscle cell membrane depolarization; • ventricular cardiac muscle cell action potential; • cell communication by electrical coupling involved in cardiac conduction; • outflow tract morphogenesis; • atrial ventricular junction remodeling; • cell communication by electrical coupling; • mitral valve development; • pulmonary valve formation; • embryonic heart tube development; • regulation of Purkinje myocyte action potential; • atrial septum morphogenesis; • cell communication; • potassium ion transport; • regulation of bundle of His cell action potential; • نماء القلب; • regulation of renin secretion into blood stream; • blood vessel development; • cardiac conduction; • embryonic limb morphogenesis; • protein complex oligomerization; • AV node cell to bundle of His cell communication by electrical coupling; • positive regulation of vasoconstriction; • توليد الأوعية; • artery morphogenesis; • نقل عبر الغشاء; • endothelium development; • renal system process involved in regulation of systemic arterial blood pressure; • regulation of systemic arterial blood pressure; • gap junction assembly; • positive regulation of cell communication by chemical coupling; • cell communication involved in cardiac conduction; • regulation of cardiac muscle contraction; • septum primum development; • regulation of heart rate by cardiac conduction; • regulation of AV node cell action potential; • negative regulation of glomerular filtration; • atrial septum development; • تغير القطر الوعائي; • foramen ovale closure; • cell communication by chemical coupling; • regulation of atrial cardiac muscle cell action potential; • regulation of ventricular cardiac muscle cell membrane repolarization; • regulation of membrane depolarization during cardiac muscle cell action potential; • SA node cell to atrial cardiac muscle cell communication by electrical coupling; • atrial cardiac muscle cell to AV node cell communication by electrical coupling; • Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling; • blood vessel diameter maintenance;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	P36382; A0A0B4J1Y3
	Q01231
	NM_181703 NM_005266، NM_181703
	NM_008121 NM_001271628، NM_008121
	NP_859054، XP_005273008، XP_016856533 NP_005257، NP_859054، XP_005273008، XP_016856533
	NP_032147 NP_001258557، NP_032147
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

GJA5‏ (Gap junction protein alpha 5) هوَ بروتين يُشَفر بواسطة جين GJA5 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ "معلومات عن GJA5 على موقع ncbi.nlm.nih.gov". ncbi.nlm.nih.gov. مؤرشف من الأصل في 2015-09-20.
^ "معلومات عن GJA5 على موقع identifiers.org". identifiers.org. مؤرشف من الأصل في 2019-12-07.
^ "معلومات عن GJA5 على موقع identifiers.org". identifiers.org. مؤرشف من الأصل في 2019-12-07.

قراءة متعمقة

Andrew L Harris؛ Darren Locke (2009). Connexins, A Guide. New York: Springer. ص. 574. ISBN:978-1-934115-46-6. مؤرشف من الأصل في 2019-12-07.
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Mehta PP؛ Lokeshwar BL؛ Schiller PC؛ وآخرون (1996). "Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP". Mol. Carcinog. ج. 15 ع. 1: 18–32. DOI:10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O. PMID:8561862.
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Kilarski WM؛ Dupont E؛ Coppen S؛ وآخرون (1998). "Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term". Eur. J. Cell Biol. ج. 75 ع. 1: 1–8. DOI:10.1016/S0171-9335(98)80040-X. PMID:9523149.
van Rijen HV، van Kempen MJ، Postma S، Jongsma HJ (1998). "Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells". Cytokine. ج. 10 ع. 4: 258–64. DOI:10.1006/cyto.1997.0287. PMID:9617570.
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Haefliger JA، Goy JJ، Waeber G (2000). "Sporadic cases of dilated cardiomyopathies associated with atrioventricular conduction defects are not linked to mutation within the connexins 40 and 43 genes". Eur. Heart J. ج. 20 ع. 24: 1843. DOI:10.1053/euhj.1999.1718. PMID:10581143.
van Rijen HV، van Veen TA، Hermans MM، Jongsma HJ (2000). "Human connexin40 gap junction channels are modulated by cAMP". Cardiovasc. Res. ج. 45 ع. 4: 941–51. DOI:10.1016/S0008-6363(99)00373-9. PMID:10728420.
Oviedo-Orta E، Hoy T، Evans WH (2000). "Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations". Immunology. ج. 99 ع. 4: 578–90. DOI:10.1046/j.1365-2567.2000.00991.x. PMC:2327182. PMID:10792506.
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[1] "معلومات عن GJA5 على موقع ncbi.nlm.nih.gov". ncbi.nlm.nih.gov. مؤرشف من الأصل في 2015-09-20.

[2] "معلومات عن GJA5 على موقع identifiers.org". identifiers.org. مؤرشف من الأصل في 2019-12-07.

[3] "معلومات عن GJA5 على موقع identifiers.org". identifiers.org. مؤرشف من الأصل في 2019-12-07.

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التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 121013
المعرفات الخارجية	Ensembl Transcript ID: ENST00000579774 نظام اللغة الطبية الموحدة (UMLS CUI): C1415073