CEP350 (англ. Centrosomal protein 350) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 3 117 амінокислот, а молекулярна маса — 350 930[5].
Послідовність амінокислот
| 10
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20
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30
|
|
40
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|
50
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| MRSSKSKEVP
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LPNPRNSQSK
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DTVQADITTS
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WDALSQTKAA
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LRHIENKLEV
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| APTSTAVCDS
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VMDTKKSSTS
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ATRKISRKDG
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RYLDDSWVNA
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PISKSTKSRK
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| EKSRSPLRAT
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TLESNVKKNN
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RVEFREPLVS
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YREIHGAPSN
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FSSSHLESKH
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| VYCVDVNEEK
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TESGNWMIGS
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REERNIRSCD
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FESSQSSVIN
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DTVVRFLNDR
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| PAIDALQNSE
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CLIRMGASMR
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TEEEMPNRTK
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GSENNLKLSV
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NNMAHDTDPK
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| ALRLTDSSPS
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STSTSNSQRL
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DILKRRQHDV
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KLEKLKERIR
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KQWEHSEETN
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| GRGQKLGHID
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HPVMVVNVDN
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SVTAKVRKVA
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TAPPAPAYKG
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FNPSETKIRT
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| PDGKVWQEAE
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FQNMSRELYR
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DLALHFADDI
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SIKEKPAEKS
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KEKKVVKPVR
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| KVQKVAQLSS
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TECRTGSSHL
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ISTSSWRDGQ
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KLVKKILGPA
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PRMEPKEQRT
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| ASSDRGGRER
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TAKSGGHIGR
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AESDPRLDVL
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HRHLQRNSER
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SRSKSRSENN
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| IKKLASSLPD
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NKQEENTALN
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KDFLPIEIRG
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ILDDLQLDST
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|
AHTAKQDTVE
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| LQNQKSSAPV
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|
HAPRSHSPVK
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RKPDKITANE
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DPPVISKRRH
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YDTDEVRQYI
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| VRQQEERKRK
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QNEEKKAQKE
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ATEQKNKRLQ
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ELYRKQKEAF
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TKVKNVPPSE
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| PSATRRLQET
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YSKLLLEKTL
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LEEPSHQHVT
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QETQAKPGYQ
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PSGESDKENK
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| VQERPPSASS
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SSDMSLSEPP
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QPLARKDLME
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STWMQPERLS
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PQVHHSQPQP
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| FAGTAGSLLS
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HLLSLEHVGI
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LHKDFESILP
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TRKNHNMASR
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PLTFTPQPYV
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| TSPAAYTDAL
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LKPSASQYKS
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KLDRIEALKA
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TAASLSSRIE
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|
SEAKKLAGAS
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| INYGSAWNTE
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YDVQQAPQED
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GPWTKAVTPP
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VKDDNEDVFS
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ARIQKMLGSC
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| VSHATFDDDL
|
|
PGVGNLSEFK
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|
KLPEMIRPQS
|
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AISSFRVRSP
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GPKPEGLLAQ
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| LCKRQTDSSS
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SDMQACSQDK
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AKISLGSSID
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SVSEGPLLSE
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GSLSEEEGDQ
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| DGQPLLKVAE
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ILKEKEFCPG
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ERNSYEPIKE
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FQKEAEKFLP
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LFGHIGGTQS
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| KGPWEELAKG
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SPHSVINIFT
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KSYQLYGKGF
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EDKLDRGTST
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|
SRPLNATATP
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| LSGVSYEDDF
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|
VSSPGTGTST
|
|
EKKSTLEPHS
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TLSPQEDHSN
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RKSAYDPSSV
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| DVTSQHSSGA
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QSAASSRSST
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SSKGKKGKKE
|
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KTEWLDSFTG
|
|
NVQNSLLDEE
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| KAERGSHQGK
|
|
KSGTSSKLSV
|
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KDFEQTLDTD
|
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STLEDLSGHS
|
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VSVSSDKGRS
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| QKTPTSPLSP
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SSQKSLQFDV
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AGTSSERSKS
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|
SVMPPTITGF
|
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KPNAPLTDLN
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| PAASRTTTEN
|
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MAPIPGSKRF
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SPAGLHHRMA
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AELSYLNAIE
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ESVRQLSDVE
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| RVRGISLAQQ
|
|
ESVSLAQIIK
|
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AQQQRHERDL
|
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ALLKLKAEQE
|
|
ALESQRQLEE
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| TRNKAAQVHA
|
|
ESLQQVVQSQ
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|
REVTEVLQEA
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TCKIAAQQSE
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TARLTTDAAR
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| QICEMAELTR
|
|
THISDAVVAS
|
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GAPLAILYDH
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QRQHLPDFVK
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|
QLRTRTETDR
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| KSPSVSLSQS
|
|
KEGTLDSKHQ
|
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KYSASYDSYS
|
|
ESSGYKNHDR
|
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RSSSGSSRQE
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| SPSVPSCKEN
|
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EKKLNGEKIE
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|
SSIDEQVQTA
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ADDSLRSDSV
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PSLPDEKDST
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| SIATEYSLKF
|
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DESMTEDEIE
|
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EQSFRSLLPS
|
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ESHRRFNMEK
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|
RRGHHDDSDE
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| EASPEKTTLS
|
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TAKELNMPFS
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|
GGQDSFSKFT
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|
MEMVRQYMKE
|
|
EEMRAAHQSS
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| LLRLREKALK
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EKTKAELAWL
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EHQKKHLRDK
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GEDDKMPPLR
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KKQRGLLLRL
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| QQEKAEIKRL
|
|
QEANKAARKE
|
|
RQLILKQQEE
|
|
IEKIRQTTIK
|
|
LQEKLKSAGE
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| SKLDSHSDDD
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TKDNKATSPG
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PTDLETRSPS
|
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PISISSSETS
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SIMQKLKKMR
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| SRMDEKFLTK
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REQKLMQRRQ
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HAEELLEWKR
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RLDAEEAEIR
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QMEKQALAAW
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| DKELIKPKTP
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KKELEDQRTE
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QKEIASEEES
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PVPLYSHLNS
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ESSIPEELGS
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| PAVEYVPSES
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IGQEQPGSPD
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HSILTEEMIC
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SQELESSTSP
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SKHSLPKSCT
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| SVSKQESSKG
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SHRTGGQCHL
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PIKSHQHCYS
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WSDESLSMTQ
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SETTSDQSDI
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| EGRIRALKDE
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LRKRKSVVNQ
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LKKEQKKRQK
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ERLKAQEASL
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|
IKQLESYDEF
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| IKKTEAELSQ
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DLETSPTAKP
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QIKTLSSASE
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KPKIKPLTPL
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HRSETAKNWK
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| SLTESERSRG
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SLESIAEHVD
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|
ASLSGSERSV
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SERSLSAYAK
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RVNEWDSRTE
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| DFQTPSPVLR
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SSRKIREESG
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DSLENVPALH
|
|
LLKELNATSR
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ILDMSDGKVG
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| ESSKKSEIKE
|
|
IEYTKLKKSK
|
|
IEDAFSKEGK
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|
SDVLLKLVLE
|
|
QGDSSEILSK
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| KDLPLDSENV
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|
QKDLVGLAIE
|
|
NLHKSEEMLK
|
|
ERQSDQDMNH
|
|
SPNIQSGKDI
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| HEQKNTKEKD
|
|
LSWSEHLFAP
|
|
KEIPYSEDFE
|
|
VSSFKKEISA
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|
ELYKDDFEVS
|
| SLLSLRKDSQ
|
|
SCRDKPQPMR
|
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SSTSGATSFG
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|
SNEEISECLS
|
|
EKSLSIHSNV
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| HSDRLLELKS
|
|
PTELMKSKER
|
|
SDVEHEQQVT
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|
ESPSLASVPT
|
|
ADELFDFHIG
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| DRVLIGNVQP
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|
GILRFKGETS
|
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FAKGFWAGVE
|
|
LDKPEGNNNG
|
|
TYDGIAYFEC
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| KEKHGIFAPP
|
|
QKISHIPENF
|
|
DDYVDINEDE
|
|
DCYSDERYQC
|
|
YNQEQNDTEG
|
| PKDREKDVSE
|
|
YFYEKSLPSV
|
|
NDIEASVNRS
|
|
RSLKIETDNV
|
|
QDISGVLEAH
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| VHQQSSVDSQ
|
|
ISSKENKDLI
|
|
SDATEKVSIA
|
|
AEDDTLDNTF
|
|
SEELEKQQQF
|
| TEEEDNLYAE
|
|
ASEKLCTPLL
|
|
DLLTREKNQL
|
|
EAQLKSSLNE
|
|
EKKSKQQLEK
|
| ISLLTDSLLK
|
|
VFVKDTVNQL
|
|
QQIKKTRDEK
|
|
IQLSNQELLG
|
|
DDQKKVTPQD
|
| LSQNVEEQSP
|
|
SISGCFLSSE
|
|
LEDEKEEISS
|
|
PDMCPRPESP
|
|
VFGASGQEEL
|
| AKRLAELELS
|
|
REFLSALGDD
|
|
QDWFDEDFGL
|
|
SSSHKIQKNK
|
|
AEETIVPLMA
|
| EPKRVTQQPC
|
|
ETLLAVPHTA
|
|
EEVEILVHNA
|
|
AEELWKWKEL
|
|
GHDLHSISIP
|
| TKLLGCASKG
|
|
LDIESTSKRV
|
|
YKQAVFDLTK
|
|
EIFEEIFAED
|
|
PNLNQPVWMK
|
| PCRINSSYFR
|
|
RVKNPNNLDE
|
|
IKSFIASEVL
|
|
KLFSLKKEPN
|
|
HKTDWQKMMK
|
| FGRKKRDRVD
|
|
HILVQELHEE
|
|
EAQWVNYDED
|
|
ELCVKMQLAD
|
|
GIFETLIKDT
|
| IDVLNQISEK
|
|
QGRMLLV
|
Кодований геном білок за функцією належить до фосфопротеїнів.
Задіяний у такому біологічному процесі як поліморфізм.
Локалізований у цитоплазмі, цитоскелеті, ядрі.
Література
- Patel H., Truant R., Rachubinski R.A., Capone J.P. (2005). Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350. J. Cell Sci. 118: 175—186. PMID 15615782 doi:10.1242/jcs.01600
- Yan X., Habedanck R., Nigg E.A. (2006). A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. Mol. Biol. Cell. 17: 634—644. PMID 16314388 doi:10.1091/mbc.E05-08-0810
- Lelievre H., Chevrier V., Tassin A.-M., Birnbaum D. (2008). Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome. Mol. Cancer. 7: 30—30. PMID 18412956 doi:10.1186/1476-4598-7-30
- Le Clech M. (2008). Role of CAP350 in centriolar tubule stability and centriole assembly. PLoS ONE. 3: E3855—E3855. PMID 19052644 doi:10.1371/journal.pone.0003855
Примітки
Див. також
