CD36

CD36
Ідентифікатори
Символи	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
Зовнішні ІД	OMIM: 173510 MGI: 107899 HomoloGene: 73871 GeneCards: CD36
Пов'язані генетичні захворювання
platelet-type bleeding disorder 10[1]
Онтологія гена Молекулярна функція • GO:0001948, GO:0016582 protein binding • low-density lipoprotein particle receptor activity • transforming growth factor beta binding • high-density lipoprotein particle binding • lipoprotein particle binding • thrombospondin receptor activity • lipid binding • low-density lipoprotein particle binding • lipoteichoic acid immune receptor activity • amyloid-beta binding • scavenger receptor activity • Toll-like receptor binding • oxidised low-density lipoprotein particle receptor activity • GO:0032403 protein-containing complex binding Клітинна компонента • комплекс Ґольджі • apical plasma membrane • phagocytic vesicle • apical part of cell • brush border membrane • endocytic vesicle membrane • integral component of plasma membrane • мембрана • external side of plasma membrane • integral component of membrane • platelet alpha granule membrane • membrane raft • cell surface • клітинна мембрана • міжклітинний простір • specific granule membrane • внутрішньоклітинний • receptor complex Біологічний процес • low-density lipoprotein particle mediated signaling • apoptotic cell clearance • positive regulation of MAPK cascade • response to lipid • nitric oxide mediated signal transduction • intestinal absorption • positive regulation of blood microparticle formation • positive regulation of blood coagulation • plasma lipoprotein particle clearance • sensory perception of taste • зсідання крові • cellular response to hydroperoxide • positive regulation of ERK1 and ERK2 cascade • receptor internalization • cellular response to bacterial lipopeptide • amyloid fibril formation • cellular response to lipopolysaccharide • cell surface receptor signaling pathway • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • cholesterol transport • platelet degranulation • cholesterol import • cellular response to diacyl bacterial lipopeptide • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0015915 транспорт • toll-like receptor TLR6:TLR2 signaling pathway • phagocytosis, recognition • cellular response to low-density lipoprotein particle stimulus • positive regulation of macrophage cytokine production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • response to linoleic acid • negative regulation of gene expression • positive regulation of reactive oxygen species metabolic process • lipoprotein transport • positive regulation of cell-matrix adhesion • positive regulation of interleukin-12 production • triglyceride transport • long-chain fatty acid import into cell • MyD88-dependent toll-like receptor signaling pathway • response to fatty acid • regulation of removal of superoxide radicals • cellular response to lipoteichoic acid • positive regulation of cholesterol storage • intestinal cholesterol absorption • positive regulation of tumor necrosis factor production • рецептор-опосередкований ендоцитоз • Обмін жирів • cGMP-mediated signaling • positive regulation of phagocytosis, engulfment • GO:0051637 defense response to Gram-positive bacterium • positive regulation of cytosolic calcium ion concentration • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • response to stilbenoid • positive regulation of NLRP3 inflammasome complex assembly • low-density lipoprotein particle clearance • lipid storage • positive regulation of macrophage derived foam cell differentiation • адгезія клітин • toll-like receptor signaling pathway • neutrophil degranulation • regulation of lipid metabolic process • production of molecular mediator involved in inflammatory response • fatty acid metabolic process • phagocytosis, engulfment • response to bacterium • GO:1901313 positive regulation of gene expression • positive regulation of cell death • cytokine-mediated signaling pathway • regulation of lipopolysaccharide-mediated signaling pathway • regulation of toll-like receptor signaling pathway • negative regulation of protein import into nucleus • regulation of protein heterodimerization activity • positive regulation of nitric oxide biosynthetic process • positive regulation of NF-kappaB transcription factor activity • energy homeostasis • regulation of action potential • positive regulation of cold-induced thermogenesis • cellular response to oxidised low-density lipoprotein particle stimulus • oxidised low-density lipoprotein particle clearance • amyloid-beta clearance by cellular catabolic process • positive regulation of reactive oxygen species biosynthetic process • cellular response to amyloid-beta Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	948	12491
Ensembl	ENSG00000135218	ENSMUSG00000002944
UniProt	P16671	Q08857
RefSeq (мРНК)	NM_000072 NM_001001547 NM_001001548 NM_001127443 NM_001127444 NM_001289908 NM_001289909 NM_001289911 NM_001371074 NM_001371075 NM_001371077 NM_001371078 NM_001371079 NM_001371080 NM_001371081	NM_001159555 NM_001159556 NM_001159557 NM_001159558 NM_007643
RefSeq (білок)	NP_000063 NP_001001547 NP_001001548 NP_001120915 NP_001120916 NP_001276837 NP_001276838 NP_001276840 NP_001358003 NP_001358004 NP_001358006 NP_001358007 NP_001358008 NP_001358009 NP_001358010	NP_001153027 NP_001153028 NP_001153029 NP_001153030 NP_031669
Локус (UCSC)	Хр. 7: 80.37 – 80.68 Mb	Хр. 5: 17.99 – 18.09 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

CD36 (англ. CD36 molecule) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 7-ї хромосоми.^[4] Довжина поліпептидного ланцюга білка становить 472 амінокислот, а молекулярна маса — 53 053^[5].

Кодований геном білок за функцією належить до рецепторів. Задіяний у таких біологічних процесах, як клітинна адгезія, транспорт, альтернативний сплайсинг. Локалізований у клітинній мембрані, мембрані, апараті гольджі.

• Хромосома 7