IER3 (Immediate early response 3) هوَ بروتين يُشَفر بواسطة جين IER3 في الإنسان.[1][2][3]
الوظيفة
الأهمية السريرية
المراجع
قراءة متعمقة
- Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis". Apoptosis. ج. 8 ع. 1: 11–8. DOI:10.1023/A:1021688600370. PMID:12510147.
- Maruyama K، Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
- Schäfer H، Trauzold A، Siegel EG، وآخرون (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line". Cancer Res. ج. 56 ع. 11: 2641–8. PMID:8653710.
- Pietzsch A، Büchler C، Aslanidis C، Schmitz G (1997). "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine". Biochem. Biophys. Res. Commun. ج. 235 ع. 1: 4–9. DOI:10.1006/bbrc.1997.6715. PMID:9196025.
- Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، وآخرون (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
- Pietzsch A، Büchler C، Schmitz G (1998). "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene". Biochem. Biophys. Res. Commun. ج. 245 ع. 3: 651–7. DOI:10.1006/bbrc.1998.8500. PMID:9588170.
- Schäfer H، Diebel J، Arlt A، وآخرون (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB". FEBS Lett. ج. 436 ع. 2: 139–43. DOI:10.1016/S0014-5793(98)01109-0. PMID:9781666.
- Kobayashi T، Pittelkow MR، Warner GM، وآخرون (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3". Biochem. Biophys. Res. Commun. ج. 251 ع. 3: 868–73. DOI:10.1006/bbrc.1998.9556. PMID:9791001.
- Kumar R، Kobayashi T، Warner GM، وآخرون (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes". Biochem. Biophys. Res. Commun. ج. 253 ع. 2: 336–41. DOI:10.1006/bbrc.1998.9692. PMID:9878538.
- Schäfer H، Arlt A، Trauzold A، وآخرون (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo". Biochem. Biophys. Res. Commun. ج. 262 ع. 1: 139–45. DOI:10.1006/bbrc.1999.1131. PMID:10448082.
- Feldmann KA، Pittelkow MR، Roche PC، وآخرون (2001). "Expression of an immediate early gene, IEX-1, in human tissues". Histochem. Cell Biol. ج. 115 ع. 6: 489–97. DOI:10.1007/s004180100284. PMID:11455449.
- Zhang Y، Schlossman SF، Edwards RA، وآخرون (2002). "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 2: 878–83. DOI:10.1073/pnas.022326699. PMC:117399. PMID:11782530.
- Im HJ، Pittelkow MR، Kumar R (2002). "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1". J. Biol. Chem. ج. 277 ع. 17: 14612–21. DOI:10.1074/jbc.M109414200. PMC:2895739. PMID:11844788.
{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
- Ohki R، Yamamoto K، Mano H، وآخرون (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". J. Hypertens. ج. 20 ع. 4: 685–91. DOI:10.1097/00004872-200204000-00026. PMID:11910304.
- Im HJ، Craig TA، Pittelkow MR، Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression". Oncogene. ج. 21 ع. 23: 3706–14. DOI:10.1038/sj.onc.1205450. PMID:12032839.
- Garcia J، Ye Y، Arranz V، وآخرون (2002). "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation". EMBO J. ج. 21 ع. 19: 5151–63. DOI:10.1093/emboj/cdf488. PMC:129026. PMID:12356731.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
جينات الكروموسوم 6 |
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