TECTA (англ. Tectorin alpha) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 2 155 амінокислот, а молекулярна маса — 239 527[5].
Послідовність амінокислот
| 10
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20
|
|
30
|
|
40
|
|
50
|
| MNYSSFLRIW
|
|
VSFIFALVQH
|
|
QAQPRELMYP
|
|
FWQNDTKTPK
|
|
VDDGSSSEIK
|
| LAIPVFFFGV
|
|
PYRTVYVNNN
|
|
GVVSFNVLVS
|
|
QFTPESFPLT
|
|
DGRAFVAPFW
|
| ADVHNGIRGE
|
|
IYYRETMEPA
|
|
ILKRATKDIR
|
|
KYFKDMATFS
|
|
ATWVFIVTWE
|
| EVTFYGGSST
|
|
TPVNTFQAVL
|
|
VSDGSYTFTL
|
|
FNYYEINWTT
|
|
GTASGGDPLT
|
| GLGGVMAQAG
|
|
FNGGNLTNFF
|
|
SLPGSRTPEI
|
|
VNIQETTNVN
|
|
VPGRWAFKVD
|
| GKEIDPANGC
|
|
TSRGQFLRRG
|
|
EVFWDDLNCT
|
|
VKCRCLDFNN
|
|
EIYCQEASCS
|
| PYEVCEPKGK
|
|
FFYCSAVETS
|
|
TCVVFGEPHY
|
|
HTFDGFLFHF
|
|
QGSCAYLLAR
|
| QCLQTSSLPF
|
|
FSVEAKNEHR
|
|
RGSAVSWVKE
|
|
LSVEVNGYKI
|
|
LIPKGSYGRV
|
| KVNDLVTSLP
|
|
VTLDLGTVKI
|
|
YQSGISTAVE
|
|
TDFGLLVTFD
|
|
GQHYASISVP
|
| GSYINSTCGL
|
|
CGNYNKNPLD
|
|
DFLRPDGRPA
|
|
MSVLDLGESW
|
|
RVYHADWKCD
|
| SGCVDNCTQC
|
|
DAATEALYFG
|
|
SDYCGFLNKT
|
|
DGPLWECGTV
|
|
VDPTAFVHSC
|
| VYDLCSVRDN
|
|
GTLLCQAIQA
|
|
YALVCQALGI
|
|
PIGDWRTQTG
|
|
CVSTVQCPSF
|
| SHYSVCTSSC
|
|
PDTCSDLTAS
|
|
RNCATPCTEG
|
|
CECNQGFVLS
|
|
TSQCVPLHKC
|
| GCDFDGHYYT
|
|
MGEFFWATAN
|
|
CTVQCLCEEG
|
|
GDVYCFNKTC
|
|
GSGEVCAVED
|
| GYQGCFPKRE
|
|
TVCLLSQNQV
|
|
LHTFDGASYA
|
|
FPSEFSYTLL
|
|
KTCPERPEYL
|
| EIDINKKKPD
|
|
AGPAWLRGLR
|
|
ILVADQEVKI
|
|
GGIGASEVKL
|
|
NGQEVELPFF
|
| HPSGKLEIYR
|
|
NKNSTTVESK
|
|
GVVTVQYSDI
|
|
GLLYIRLSTT
|
|
YFNCTGGLCG
|
| FYNANASDEF
|
|
CLPNGKCTDN
|
|
LAVFLESWTT
|
|
FEEICNGECG
|
|
DLLKACNNDS
|
| ELLKFYRSRS
|
|
RCGIINDPSN
|
|
SSFLECHGVV
|
|
NVTAYYRTCL
|
|
FRLCQSGGNE
|
| SELCDSVARY
|
|
ASACKNADVE
|
|
VGPWRTYDFC
|
|
PLECPENSHF
|
|
EECITCTETC
|
| ETLTLGPICV
|
|
DSCSEGCQCD
|
|
EGYALLGSQC
|
|
VTRSECGCNF
|
|
EGHQLATNET
|
| FWVDLDCQIF
|
|
CYCSGTDNRV
|
|
HCETIPCKDD
|
|
EYCMEEGGLY
|
|
YCQARTDASC
|
| IVSGYGHYLT
|
|
FDGFPFDFQT
|
|
SCPLILCTTG
|
|
SRPSSDSFPK
|
|
FVVTAKNEDR
|
| DPSLALWVKQ
|
|
VDVTVFGYSI
|
|
VIHRAYKHTV
|
|
LVNSERLYLP
|
|
LKLGQGKINI
|
| FSFGFHVVVE
|
|
TDFGLKVVYD
|
|
WKTFLSITVP
|
|
RSMQNSTYGL
|
|
CGRYNGNPDD
|
| DLEMPMGLLA
|
|
SSVNEFGQSW
|
|
VKRDTFCQVG
|
|
CGDRCPSCAK
|
|
VEGFSKVQQL
|
| CSLIPNQNAA
|
|
FSKCHSKVNP
|
|
TFFYKNCLFD
|
|
SCIDGGAVQT
|
|
ACSWLQNYAS
|
| TCQTQGITVT
|
|
GWRNYTSCTV
|
|
TCPPNSHYES
|
|
CVSVCQPRCA
|
|
AIRLKSDCSH
|
| YCVEGCHCDA
|
|
GYVLNGKSCI
|
|
LPHSCGCYSD
|
|
GKYYEPKQLF
|
|
WNSDCTRRCR
|
| CFRRNVIQCD
|
|
PRQCKSDEEC
|
|
ALRNGVRGCF
|
|
STKTSYCLAA
|
|
GGGVFRTFDG
|
| AFLRFPANCA
|
|
FVLSTICQKL
|
|
PDISFQLIIN
|
|
FDKWSAPNLT
|
|
IISPVYFYIN
|
| EEQILINDRN
|
|
TVKVNGTQVN
|
|
VPFITGLATK
|
|
IYSSEGFLVI
|
|
DTSPDIQIYY
|
| NGFNVIKISI
|
|
SERLQNKVCG
|
|
LCGNFNGDLT
|
|
DDYVTLRGKP
|
|
VVSSVVLAQS
|
| WKTNGMQKRP
|
|
LAPSCNELQF
|
|
SQYAAMCDNV
|
|
HIQKMQGDGY
|
|
CLKLTDMKGF
|
| FQPCYGLLDP
|
|
LPFYESCYLD
|
|
GCYSHKKFQL
|
|
CGSLAAYGEA
|
|
CRSFGILSTE
|
| WIEKENCSGV
|
|
VEDPCVGADC
|
|
PNRTCELGNG
|
|
RELCGCIEPP
|
|
PYGNNSHDII
|
| DAEVTCKAAQ
|
|
MEVSISKCKL
|
|
FQLGFEREGV
|
|
RINDRQCTGI
|
|
EGEDFISFQI
|
| NNTKGNCGNI
|
|
VQSNGTHIMY
|
|
KNTLWIESAN
|
|
NTGNIITRDR
|
|
TINVEFSCAY
|
| ELDIKISLDS
|
|
VVKPMLSVIN
|
|
LTVPTQEGSF
|
|
ITKMALYKNA
|
|
SYKHPYRQGE
|
| VVLTTRDVLY
|
|
VGVFVVGADA
|
|
THLILTLNKC
|
|
YATPTRDSND
|
|
KLRYFIIEGG
|
| CQNLKDNTIG
|
|
IEENAVSLTC
|
|
RFHVTVFKFI
|
|
GDYDEVHLHC
|
|
AVSLCDSEKY
|
| SCKITCPHNS
|
|
RIATDYTKEP
|
|
KEQIISVGPI
|
|
RRKRLDWCED
|
|
NGGCEQICTS
|
| RVDGPLCSCV
|
|
TGTLQEDGKS
|
|
CRASNSSMEL
|
|
QVWTLLLIMI
|
|
QISLWHFVYK
|
| SGTTS
|
Локалізований у клітинній мембрані, мембрані, позаклітинному матриксі.
Також секретований назовні.
Література
- Meyer N.C., Nishimura C.J., McMordie S., Smith R.J. (2007). Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree. Clin. Genet. 72: 130—137. PMID 17661817 doi:10.1111/j.1399-0004.2007.00828.x
Примітки
Див. також
